منابع مشابه
Biosynthesis of Germacrene A Carboxylic Acid in Chicory Roots. Demonstration of a Cytochrome P450 (1)-Germacrene A Hydroxylase and NADP-Dependent Sesquiterpenoid Dehydrogenase(s) Involved in Sesquiterpene Lactone Biosynthesis
Sprouts of chicory (Cichorium intybus), a vegetable grown in the dark, have a slightly bitter taste associated with the presence of guaianolides, eudesmanolides, and germacranolides. The committed step in the biosynthesis of these compounds is catalyzed by a (1)-germacrene A synthase. Formation of the lactone ring is the postulated next step in biosynthesis of the germacrene-derived sesquiterpe...
متن کاملChemoenzymatic preparation of germacrene analoguesw
Terpenoids represent a valuable class of bioactive fine chemicals and are therefore attractive targets for synthetic modification; modulation of their natural properties may lead to new medicinal and agrochemical compounds with improved properties. However, the complexity of the hydrocarbon skeletons and the often significant chemical instability of many terpenoids can present a formidable chal...
متن کاملChemoenzymatic preparation of germacrene analogues.
A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.
متن کاملGermacrene D Cyclization: An Ab Initio Investigation
Essential oils that contain large concentrations of germacrene D are typically accompanied by cadinane sesquiterpenoids. The acid-catalyzed cyclization of germacrene D to give cadinane and selinane sesquiterpenes has been computationally investigated using both density functional (B3LYP/6-31G(*)) and post Hartree-Fock (MP2/6-31G(* *)) ab initio methods. The calculated energies are in general ag...
متن کاملGermacrene D, a common sesquiterpene in the genus Bursera (Burseraceae).
The volatile components of the leaves of five Bursera species, B. copallifera, B. exselsa, B. mirandae, B. ruticola and B. fagaroides var. purpusii were determined by gas chromatography-mass spectrometry (GC-MS). Germacrene D was one of the predominant components (15.1-56.2%) of all of these species. Germacrene D has also been found in other Bursera species and some species of Commiphora, the s...
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ژورنال
عنوان ژورنال: Plant Physiology
سال: 1998
ISSN: 1532-2548,0032-0889
DOI: 10.1104/pp.117.4.1381